I hestitate to post this, because it seems so basic that I must be playing the game wrong, but:
I cannot shoot in certain directions with certain characters. For the ranger, I can't shoot Southwest. When pressing the Hold key (LShift) I can't shoot Southwest, South, or Southeast. There is no sound or animation.
With the Warlock, I can't shoot Southwest, or any southern direction with the dagger. With the lightning blast, I can't shoot Northwest, or any Western direction with the Hold key on.
The other characters have some bugs too. I'm using Windows 7 x64 on an Alienware machine.
Anyone else experienced this?